48. SURVEY OF ANTI-MULLERIAN HORMONE CONCENTRATION IN INFERTILITY PATIENTS AT THE DEPARTMENT OF ASISTED REPRODUCTIVE THAI NGUYEN A HOSPITAL
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Abstract
Objective: To survey AMH levels and determine the response point to ovarian stimulation therapy of AMH levels in infertile and subfertile patients.
Subjects and methods: A cross-sectional study was conducted on 278 female patients of reproductive age (18-45 years old), diagnosed with infertility (primary or secondary) and treated with ovarian stimulation at the Department of Reproductive Support, Thai Nguyen A Hospital.
Results: The average AMH concentration in the study was 3.93 ± 2.89 (ng/mL), the median value was 3.0 ng/mL, the maximum value was 16.7ng/ml and the minimum was 0.243ng/mL. The average AMH concentration and the number of reserve oocytes are inversely proportional to the patient's age, especially after the age of 35, it is only half of that of the age of 19-24. The AMH concentration is moderately positively correlated with the number of oocytes obtained after ovarian stimulation. When the AMH concentration is ≤ 1.1 ng/mL, it shows that the patient responds poorly or almost does not respond to ovarian stimulation. With an AMH concentration = 1.2 ng/mL, the patient responds poorly to ovarian stimulation, an AMH concentration of 3.1-4.4 ng/mL, the patient responds well to ovarian stimulation, greater than 4.5 ng/mL is the threshold value for excessive response to ovarian stimulation.
Conclusions: AMH concentration decreases with age and positively correlates with the number of oocytes obtained after ovarian stimulation. The threshold of AMH that responds well to ovarian stimulation is 4.5 ng/mL.
Article Details
Keywords
AMH, ovarian stimulation
References
[2] Rey R et al, Anti-müllerian hormone is a specific marker of sertoli- and granulosa-cell origin in gonadal tumors, Hum Pathol, 2000, 31 (10), p. 1202-8.
[3] Visser J.A et al, Anti-müllerian hormone: a new marker for ovarian function, Reproduction, 2006, 131 (1), p. 1-9.
[4] Vũ Văn Tâm, Dương Thọ Quỳnh Hương, Đỗ Diễm Hường, So sánh giá trị của amh, AFC và FSH trong dự đoán đáp ứng buồng trứng trên bệnh nhân làm thụ tinh trong ống nghiệm tại Bệnh viện Phụ Sản Hải Phòng, Nội tiết, vô sinh và hỗ trợ sinh sản, 2018, tập 16 số 01, tr. 160-163.
[5] Arce J.C et al, Anti-müllerian hormone in gonadotropin releasing-hormone antagonist cycles: prediction of ovarian response and cumulative treatment outcome in good-prognosis patients, Fertil Steril, 2013, 99 (6), p. 1644-53.
[6] Kelsey T.W et al, A validated model of serum anti-müllerian hormone from conception to menopause, PLoS One, 2011, 6 (7), p. e22024.
[7] Moolhuijsen, L.M.E, J.A, Visser, anti-müllerian hormone and ovarian reserve: Update on Assessing Ovarian Function, J Clin Endocrinol Metab, 2020, 105 (11), p. 3361-73.
[8] ĐàoThị Thúy Phượng, Nguyễn Khang Sơn, Mai Thị Giang, Đánh giá mối liên quan giữa nồng độ AMH huyết thanh và kết quả thụ tinh trong ống nghiệm, Tạp chí Y học Việt Nam, 2021, 507 (2).
[9] Vương Thị Ngọc Lan, Võ Minh Tuấn, So sánh giá trị dự đoán của AMH, FSH và AFC đối với đáp ứng kém hủy chu kỳ do không nang phát triển ở bệnh nhân thụ tinh ống nghiệm, Tạp chí Phụ Sản, 2014, tập 12, số 01, tr. 28-33.