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Published: 2025-03-04
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DOI: https://doi.org/10.52163/yhc.v66i2.2060
Issue
Vol. 66 No. 2
Section
Articles
How to Cite
Hà, N. T., & Lượng, Đinh V. (2025). 24. PLASMA PROCALCITONIN AND C-REACTIVE PROTEIN OF INPATIENTS WITH ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT THE NATIONAL LUNG HOSPITAL. Vietnam Journal of Community Medicine, 66(2). https://doi.org/10.52163/yhc.v66i2.2060

24. PLASMA PROCALCITONIN AND C-REACTIVE PROTEIN OF INPATIENTS WITH ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT THE NATIONAL LUNG HOSPITAL

Nguyen Thanh Ha1, Dinh Van Luong1
1 National Lung Hospital

Main Article Content

Abstract

Objective: To describe the clinical and paraclinical characteristics as well as plasma levels of Procalcitonin (PCT) and C-reactive protein (CRP) of inpatients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) at the National Lung Hospital.


Subject and method: A cross-sectional study was conducted on 200 patients diagnosed with AECOPD and admitted to the National Lung Hospital from November 2023 to May 2024.


Results: Most patients were male (91.5%), aged 60-79 years (76.0%). The highest mean FEV1 percentage was observed in GOLD 1 (91.67 ± 8.12) and the lowest in GOLD 4 (23.23 ± 4.59). Plasma CRP and PCT levels were highest in exacerbation grade I and GOLD 4, at 85.9 (96.61 ± 59.29) mg/L; 3.03 (9.54 ± 46.10) ng/mL and 92.1 (107.71 ± 53.03) mg/L; 4.06 (14.09 ± 67.53) ng/mL, respectively, and lowest in grade III and GOLD 1, at 56.95 (63.94 ± 36.22) mg/L; 0.25 (0.27 ± 0.20) ng/mL and 61.35 (64.23 ± 31.80) mg/L; 0.39 (0.29 ± 0.20) ng/mL, respectively, with statistical significance (p < 0.05).


Conclusion: CRP and PCT are reliable biomarkers reflecting the severity and stages of AECOPD, effectively supporting diagnosis and treatment.

Article Details

Keywords

acute exacerbations of chronic obstructive pulmonary disease (AECOPD), Procalcitonin (PCT) and C-reactive protein (CRP)

References

[1] 1Huỳnh Đình Nghĩa (2019), "Nghiên cứu nồng độ Procalcitonin huyết thanh ở bệnh nhân nam đợt cấp bệnh phổi tắc nghẽn mạn tính có hứt thuốc lá ", Tạp chí Y Dược học Cần Thơ. 7, tr. 22-25.
[2] 2Cung Văn Tấn (2019), Nghiên cứu đặc điểm lâm sàng, cận lâm sàng, vi khuẩn gây bệnh và kết quả điều trị viêm phổi cộng đồng ở bệnh nhân bệnh phổi tắc nghẽn mạn tính tại Bệnh viện Phổi Trung ương Luận văn Bác sĩ chuyên khoa IIĐại học Y Hà Nội.
[3] Thái Thị Thùy Linh (2020), Giá trị của CRP, INTERLEUKIN-6 và Bảng câu hỏi CAT trong chẩn đoán đợt cấp bệnh phổi tắc nghẽn mạn tính Luận án Tiến sỹTrường Đại học Y Dược thành phố Hồ Chí Minh.
[4] 4Alvar Agustí, et al. (2023), "Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary", European Respiratory Journal. 61(4).
[5] 5NR Anthonisen, et al. (1987), "Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease", Annals of internal medicine. 106(2), p. 196-204.
[6] Johannes MA Daniels, et al. (2010), "Procalcitonin vs C-reactive protein as predictive markers of response to antibiotic therapy in acute exacerbations of COPD", Chest. 138(5), p. 1108-1115.
[7] Leoardo M Fabbri, SS Hurd (2003), "Global strategy for the diagnosis, management and prevention of COPD: 2003 update", European Respiratory Journal. 22(1), p. 1-1.
[8] Daiana Stolz, et al. (2007), "Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD", Chest. 131(4), p. 1058-1067.
[9] Jiarui Zhang, et al. (2024), "A simple clinical risk score (ABCDMP) for predicting mortality in patients with AECOPD and cardiovascular diseases", Respiratory Research. 25(1), p. 89.
[10] Wen Zhou, Jie Tan (2021), "The expression and the clinical significance of eosinophils, PCT and CRP in patients with acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary infection", American Journal of Translational Research. 13(4), p. 3451.